Dormant Hair Follicles to be More Effectively Revitalized by Nutrients and Therapeutics Delivered Quickly and Potently via Extremely Fine Droplet Sizes Produced from Patented UST Nanoemulsion Technology

SOUTH EASTON, MA / ACCESSWIRE / October 26, 2022 / Pressure BioSciences, Inc. (OTCQB:PBIO) (“PBI” or the “Company”), a leader in the development and sale of broadly enabling, pressure-based instruments, consumables, and specialty testing services to the worldwide cosmetics, nutraceuticals, biotherapeutics, and food/beverage industries, among others, today confirmed specific product rollout plans agreed in their wide-ranging partnership with science-driven skincare industry leader Dr. Denese SkinScience, which were shared recently in the FORCE Family Office sponsored Development of a New Generation of Skincare Products webinar (PBIO/Dr. Denese FORCE Webinar 101322). Highlighting Dr. Denese’s world renown expertise and long-established leadership role as an innovator in skincare, the webinar revealed that the two companies had chosen three additives/areas for their initial collaborative development of valuable new skincare product lines, all of which would leverage PBI’s proprietary UST nanoemulsification process: (i) retinol, (ii) lipid-soluble Vitamin C, and (iii) hair loss prevention/hair regrowth.

Dr. Adrienne Denese, M.D., Ph.D. a globally-acknowledged skincare visionary, anti-aging pioneer, and President of Dr. Denese SkinScience, explained: “The pivotal challenge in cosmeceuticals and skincare products is to deliver our scientifically designed payloads of critical nutrient and therapeutic ingredients in a speedy, complete, and precise fashion while penetrating through the difficult resistive barrier of skin down to the living dermal tissues beneath it. So many of these key ingredients are “oily” or lipophilic molecules that do not normally mix well with water, making them difficult to effectively deliver for absorption by the water-based biochemistry of human bodies. The revolutionary breakthrough of PBI’s industrially-scalable UST platform technology for making nanoemulsions of extremely-fine nano-droplet sizes, that are subsequently stable and can deliver nutrients and therapeutic payloads with unprecedented effectiveness, is undoubtedly one of the most important scientific and process breakthroughs for our industry in my lifetime.”

Dr. Denese continued: “From my patients and customers, the single most-requested addition to our product line is an effective intervention for hair loss and hair regeneration – and it is considered vastly more urgent in age-related hair loss for women, beyond the enormous demand amongst men. We believe that the challenge of truly effective delivery of stimulation and revitalization to weakening and dormant hair follicles will finally be overcome with the entry of PBI’s UST nanoemulsions platform technology, and we are now planning to deliver an effective solution to that challenge. In just a few weeks since making this decision, my team and I have made tremendous progress on the development of our first-ever hair loss prevention/hair restoration product line. With progress to date, we are now targeting to launch the first products in this new, exciting product line in time for the Christmas 2023 buying season. What a gift that would be for our existing and loyal base of over 500,000 QVC customers and for many more eager new buyers!”

Gary Smejkal, Senior Scientist at PBI, said: “We have also made wonderful progress lately in the development of UST-processed retinol and lipid-soluble Vitamin C. These very high quality nanoemulsions consist of oil droplets that are consistent and extremely small. At about 50 nanometers they are far smaller than the wavelength of visible light, which makes them highly transparent; they are also expected to be stable and effectively water soluble. These initial nutrients and therapeutic nanoemulsion ingredients should be available to Dr. Denese SkinScience for inclusion in their skincare products by the middle of 2023.”

Richard T. Schumacher, President and CEO of PBI, summed up the progress: “We believe that PBI’s UST nanoemulsified retinol and lipid-soluble Vitamin C enhanced products will add valuable new dimensions to multiple Dr. Denese SkinScience products starting in mid-2023. Most excitingly, it appears now that the new hair loss prevention/hair restoration product line should be ready for marketing in about one year, which means these products could add millions in revenue to PBI’s 2023 results. This would be additive to the approximately five million dollars in revenue we believe will be received in 2023 from completion of the three new nano-CBD contracts that have announced over the past several months and that we expect to complete in 2023, with shipments beginning in next year’s first quarter.”

Mr. Schumacher concluded: “Dr. Adrienne Denese is a titan in the cosmeceuticals/skincare industry worldwide and has accumulated sales over $500 million through QVC alone! Her life mission has been to help women look and feel younger and to live healthier lives. She has relentlessly focused on science, quality, potency, and effectiveness in her products over all else. We feel immensely privileged to have won her support and close partnership between our companies. These are indeed very exciting times for all stakeholders in PBIO.”

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (OTCQB:PBIO) is a leader in the development and sale of innovative, broadly enabling, pressure-based solutions for the worldwide life sciences and other industries. Our products are based on the unique properties of both constant (i.e., static) and alternating (i.e., pressure cycling technology, or PCT) hydrostatic pressure. PCT is a patented enabling technology platform that uses alternating cycles of hydrostatic pressure between ambient and ultra-high levels to control bio-molecular interactions safely and reproducibly (e.g., cell lysis, biomolecule extraction). Our primary focus is in the development of PCT-based products for biomarker and target discovery, drug design and development, biotherapeutics characterization and quality control, soil & plant biology, forensics, and counter-bioterror applications. Additionally, major new market opportunities have emerged in the use of our pressure-based technologies in the following areas: (1) the use of our recently acquired, patented technology from BaroFold, Inc. (the “BaroFold” technology) to allow entry into the bio-pharma contract services sector, and (2) the use of our recently-patented, scalable, high-efficiency, pressure-based Ultra Shear Technology (“UST”) platform to (i) create stable nanoemulsions of otherwise immiscible fluids (e.g.,oils and water) and to (ii) prepare higher quality, homogenized, extended shelf-life or room temperature stable low-acid liquid foods that cannot be effectively preserved using existing non-thermal technologies.

Forward Looking Statements

This press release contains forward-looking statements. These statements relate to future events or our future financial performance and involve known and unknown risks, uncertainties and other factors that may cause our or our industry’s actual results, levels of activity, performance, or achievements to be materially different from any future results, levels of activity, performance or achievements expressed, implied, or inferred by these forward-looking statements. In some cases, youcan identify forward-looking statements by terminology such as “may,” “will,” “should,””could,””would,” “expects,” “plans,” “intends,””anticipates,” “believes,” estimates,””predicts,” “projects,””potential” or “continue” or the negative of such terms and other comparable terminology. These statements are only predictions based on our current expectations and projections about future events. You should not placeundue reliance on these statements. In evaluating these statements, you should specifically consider various factors. Actual events or results may differ materially. These and other factors may cause our actual results to differ materially fromany forward-looking statement. These risks, uncertainties, and other factors include, but are not limited to, the risks and uncertainties discussed under the heading “Risk Factors” in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, and other reports filed by the Company from time to time with the SEC. The Company undertakes no obligation to update any of the information included in this release, except as otherwise required by law.

Companies Will Discuss Actions and Planning Completed for a New Generation of Skincare Products, Offering Revolutionary Effectiveness Through Combination of PBI’s UST Best-in-Class Nanoemulsification Technology with Dr. Denese’s Unparalleled Science-Driven Understanding of the Needs in the Skincare Market

SOUTH EASTON, MA / ACCESSWIRE / October 11, 2022 / Pressure BioSciences, Inc. (OTCQB:PBIO) (“PBI” and the “Company”), a leader in the development and sale of innovative, broadly enabling, pressure-based instruments, consumables, and specialty testing services to the worldwide cosmeceuticals, health and wellness, and other industries today announced the Company’s participation in the October 13^th Development of a New Generation of Skincare Products webinar, sponsored by FORCE Family Office. PBI is honored to be joined by QVC icon, skincare visionary, and anti-aging pioneer Adrienne Denese, M.D., Ph.D. Dr. Denese is the President of Dr. Denese SkinScience, one of the most successful skincare lines in the U.S., with accumulated sales over $500 million through QVC.

PBI’s revolutionary Ultra Shear Technology™ (UST™) platform, and its’ critical enabling role in the development of a new generation of skincare products, will be the focus of this real-time, interactive “Presentation/Q&A Event”. UST is a revolutionary and industrially-scalable technology that can process oil and water mixtures into nanoemulsions, in which large oil drops in water (containing active ingredients) are reduced to nano-sized oil droplets so small they achieve effective water-solubility and long-term stability. These high quality nanoemulsions show significantly increased absorption and bioavailability of the therapeutic active ingredients contained in the nano-sized oil droplets. Examples of active ingredients include retinol, vitamins, supplements, and nutraceuticals – all of which are routinely infused into cosmeceuticals.

Dr. Adrienne Denese’s life mission has been to help women look and feel younger, and to live healthier lives. Her immutable priority has always been to effectively develop and deliver the highest quality active ingredients to her customers. Dr. Denese explained: “I am excited to partner with PBI as we together use the UST platform’s remarkable breakthrough in nanoemulsion effectiveness to develop a new generation of category-changing skincare products that will offer more effective absorption, bioavailability, and therapeutic benefits to Dr. Denese SkinScience customers worldwide.”

DATE: Thursday, October 13, 2022 (Noon ET)
PRESENTATION: Video Webcast
REGISTER: Click here to register for the Webinar

Panelists

• Pressure BioSciences, Inc. (OTCQB:PBIO) announced on Wednesday, September 28^th the imminent commercial launch of its revolutionary UST nanoemulsification processing method, with an initial focus in the CBD market. Company expects Q4 2022 incremental revenue to be in the hundreds of thousands of dollars and in the millions of dollars for FY 2023. Mr. Richard T. Schumacher, Founder and CEO, will be a panel participant.
• Dr. Denese SkinScience is one of the most successful, highly-rated, award-winning, and longest-lasting skincare lines in the history of QVC. Dr. Adrienne Denese, Founder and President, will be a panel participant.
• FORCE Family Office is the largest network of family offices in the United States. FORCE is dedicated to helping family offices efficiently and successfully connect with private and public companies for co-investment, research, education, and philanthropy. CEO Steven Saltzstein will be the Moderator of the webinar.

Selected Recent Key Announcements – PBIO

• Pressure BioSciences Secures Pivotal Cosmeceuticals Partnership for UST Platform with Dr. Denese SkinScience, 20-Year Industry Leader with Over $0.5 Billion in QVC Sales.
• Pressure BioSciences Announces First Nanoemulsions Manufacturing Agreement Under Recently Released UST Early Access Program

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (OTCQB:PBIO) is a leader in the development and sale of innovative, broadly enabling, pressure-based solutions for the worldwide life sciences and other industries. Our products are based on the unique properties of both constant (i.e., static) and alternating (i.e., pressure cycling technology, or PCT) hydrostatic pressure. PCT is a patented enabling technology platform that uses alternating cycles of hydrostatic pressure between ambient and ultra-high levels to control bio-molecular interactions safely and reproducibly (e.g., cell lysis, biomolecule extraction). Ourprimary focus is the development of PCT-based products for biomarker and target discovery, drug design and development, biotherapeutics characterization and quality control, soil & plant biology, forensics, and counter-bioterror applications. Additionally, major new market opportunities have emerged in the use of our pressure-based technologies in the following areas: (1) the use of our recently acquired, patented technology from BaroFold, Inc. (the “BaroFold” technology) to allow entry into the bio-pharma contract services sector, and (2) the use of our recently-patented, scalable, high-efficiency, pressure-based Ultra Shear Technology (“UST”) platform to (i) create stable nanoemulsions of otherwise immiscible fluids (e.g.,oils and water) and to (ii) prepare higher quality, homogenized, extended shelf-life or room temperature stable low-acid liquid foods that cannot be effectively preserved using existing non-thermal technologies.

Forward Looking Statements

This press release contains forward-looking statements. These statements relate to future events or our future financial performance and involve known and unknown risks, uncertainties and other factors that may cause our or our industry’s actual results, levels of activity, performance, or achievements to be materially different from any future results, levels of activity, performance or achievements expressed, implied, or inferred by these forward-looking statements. In some cases, youcan identify forward-looking statements by terminology such as “may,” “will,” “should,””could,””would,” “expects,” “plans,” “intends,””anticipates,” “believes,” estimates,””predicts,” “projects,””potential” or “continue” or the negative of such terms and other comparable terminology. These statements are only predictions based on our current expectations and projections about future events. You should not placeundue reliance on these statements. In evaluating these statements, you should specifically consider various factors. Actual events or results may differ materially. These and other factors may cause our actual results to differ materially fromany forward-looking statement. These risks, uncertainties, and other factors include, but are not limited to, the risks and uncertainties discussed under the heading “Risk Factors” in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, and other reports filed by the Company from time to time with the SEC. The Company undertakes no obligation to update any of the information included in this release, except as otherwise required by law.